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AIM CellSparc 360® Details

The cardiovascular system consists of the heart and blood vessels. Heart disease is the biggest killer in North America. It includes structural or functional abnormalities of the heart, or of the blood vessels supplying the heart, that impair its normal functioning.

Cholesterol contributes to buildup of plaque in the coronary arteries that restricts blood flow to the heart, causing chest pain, and possibly leading to heart attack and death.

In addition to eating a nutritious diet and getting adequate exercise, supplementation with coenzyme Q10 (CoQ10), tocotrienols, and fish oil can help maintain heart health.

Coenzyme Q10

All living cells require adenosine triphosphate (ATP) to function. ATP represents a major source of stored energy in the body and is responsible for many metabolic processes. CoQ10 is key in the production of ATP.

CoQ10, or ubiquinone, is found throughout the body in cell membranes, especially mitochondrial membranes, the areas of cells where food is converted to energy. According to a 1990 article in the American Journal of Cardiology, “Coenzyme Q10 is necessary for the mitochondria to perform their functions and is essential for human life.” CoQ10 is most abundant in the heart, lungs, liver, kidneys, and spleen.

Without adequate levels of CoQ10, the body cannot produce adequate levels of ATP. When you consider that the average person uses 60 percent of his or her daily energy alone on base metabolism, you can see how important CoQ10 is in ensuring that the body is able to create enough energy for both its millions of everyday tasks and its special energy needs.

In the mid-1960s, Japanese professor Yamamura was the first clinician to use coenzyme Q7 (a compound related to CoQ10) in the treatment of congestive heart failure. Since then, numerous clinical trials have demonstrated the efficacy of CoQ10 in promoting cardiac health (Langsjoen et al. 1994, Greenberg and Frishman 1990).

A recent literature review looked at clinical trials, articles, reviews, and letters published during the past 25 years in regard to the role of CoQ10 in heart failure (Tran et al. 2001). The review indicates that CoQ10 helps in how efficiently the heart pumps (ejection fraction), how well the heart functions when it is made to work harder (exercise tolerance), how much blood is pumped by the heart (stroke volume), and how much blood the heart can pump in one minute (cardiac output.)

Japanese researchers have also found that CoQ10 supplementation prior to and immediately following open-heart surgery is highly beneficial in preventing injuries related to reperfusion, restoring blood flow to organs and tissues.

Studies also indicate that CoQ10 supplementation may decrease the amount of medication used by heart disease patients, improve health as measured by the New York Heart Association functional scale, improve overall quality of life for heart patients, and act to maintain healthy blood pressure levels.

In addition to cardiac benefits, CoQ10 has been positively researched with regard to periodontal disease, athletic performance (stressful exercise reduces blood levels of CoQ10), muscular dystrophy, immunity and infections, and HIV.

CoQ10 also seems to be a helpful secondary therapy in some cancers. This is supported by research in regard to colon and prostatic cancers and anecdotal reports in relation to pancreatic and lung cancer.

Tocotrienols

Tocotrienols are a form of vitamin E. The term “vitamin E” actually describes a group of eight fat-soluble compounds—alpha-, beta-, delta-, and gamma-tocopherol and alpha-, beta-, delta-, and gammatocotrienol. Usually, vitamin E is loosely used to refer to as alpha-tocopherol.

Tocotrienols are found in cereal seeds and rice bran, and in palm and barley oils. Research indicates that tocotrienols have antitumor and antioxidant properties and may reduce cholesterol.

In one study, 90 people with high cholesterol levels followed the American Heart Association (AHA) Step-1 diet and took 100 mg of tocotrienols for a 35-day period.

This program reduced their total cholesterol levels 20 percent and their LDL cholesterol levels—the “bad cholesterol”—25 percent compared to their cholesterol levels at the beginning of the study (Qureshi et al. 2002).

Another study (Serbinova and Packer 1994) shows that tocotrienols have 40 to 60 times more antioxidant ability than alpha-tocopherol—vitamin E.

Fish oil

Diets high in saturated fats have been linked to high blood cholesterol levels. Epidemiological studies have shown that in populations where large amounts of fish are consumed, there is little evidence of heart disease.

The U.S. Physicians’ Health Study found that men who consumed fish one time per week cut their risk of sudden cardiac death by 52 percent compared with men who ate fish less than one time per month (Albert, et al. 1998).

A recent meta-analysis indicated that the use of dietary and supplemental omega-3 polyunsaturated fatty acids reduces overall mortality, mortality due to myocardial infarction, and sudden death in patients with coronary heart disease (Bucher et al. 2002).

Fish oil has also been found to help reduce triglyceride— a type of fat—levels. High triglyceride levels are a factor in heart disease.

Fish oils are rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are believed to decrease the risk of thrombosis (blood clot) and lower blood pressure.

In addition to its health benefits, fish oil is used in AIM CellSparc 360® as a dissolvent for the CoQ10 and tocotrienols. Dr. Karl Folkers, the doctor responsible for much of the research on CoQ10, recommends that it be dissolved in oil. Because CoQ10 is fat-soluble, it requires fat to be absorbed by the digestive tract.

A softgel delivery system can increase the absorption of the product. A double-blind, controlled study shows that an oil-diluent softgel CoQ10 formulation has an absorption rate almost three times higher than that of a dry capsule CoQ10 formulation.

An oil-diluent softgel formulation resulted in a CoQ10 blood level of 265 percent over the base level, while a dry capsule form of CoQ10 resulted in a blood level of 180 percent over the base level.

The dry capsule CoQ10 was absorbed at 3.4 micrograms per minute, while the oil-diluent softgel CoQ10 was absorbed at 9.3 micrograms per minute—a 273 percent difference. This greater bioavailability appears to affect energy. Results show that 83 percent of those who used the oil-diluent softgel form experienced more energy, compared to 30 percent of those who used the dry capsule form.

References

• Albert, C.M., et al. “Fish Consumption and Risk of Sudden Cardiac Death.” Journal of the American Medical Association 279 (1998): 23-28.
• Bucher, H.C., et al. “N-3 [Omega-3] Polyunsaturated Fatty Acids in Coronary Heart Disease: A Meta-Analysis of Randomized Controlled Trials.” American Journal of Medicine 112, no. 4 (2002): 298-304.
• Greenberg, A., and W. Frishman. “Coenzyme Q10: A New Drug for Cardiovascular Health.” Journal of Clinical Pharmacology 30, no. 7 (July 1990): 596-608.
• Langsjoen, P., P. Langsjoen, R. Willis, and K. Folkers. “Treatment of Essential Hypertension with Coenzyme Q10.” Molecular Aspects of Medicine 15 Suppl (1994): S265-272.
• Qureshi, A.A., et al. “Dose-Dependent Suppression of Serum Cholesterol by Tocotrienol-Rich Fraction (TRF(25)) of Rice Bran in Hypercholesterolemic Humans.” Atherosclerosis 161, no. 1 (2002): 199-207.
• Serbinova, E.A., and L. Packer. “Antioxidant Properties of Alpha-Tocopherol and Alpha-Tocotrienol.” Methods Enzymol. 234 (1994): 354-366.
• Tran, M.T., et al. “Role of Coenzyme Q10 in Chronic Heart Failure, Angina, and Hypertension.” Pharmacotherapy 21, no. 7 (2001): 797-806.

The complete Cardio Health line consists of AIM CellSparc 360 and AIM Bear Paw Garlic. Use these products to help yourself maintain cardiovascular health. Complimentary Products are AIM GinkgoSense™, AIM Proancynol® 2000, and AIMega™.

The complete Senior's Support line consists of AIM CellSparc 360, AIM PrepZymes®, and AIM GinkgoSense™. Complimentary Product: AIMega™. Use these products to help yourself maintain Senior's health.

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